Annual report pursuant to Section 13 and 15(d)

CONSOLIDATED STATEMENT OF STOCKHOLDERS' EQUITY (DEFICIT)

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CONSOLIDATED STATEMENT OF STOCKHOLDERS' EQUITY (DEFICIT) - USD ($)
$ in Thousands
Series D Preferred Stock [Member]
Common Stock [Member]
Cashless Exercise of Warrants [Member]
Series D Preferred Stock [Member]
Common Stock [Member]
Cashless Exercise of Options [Member]
Series D Preferred Stock [Member]
Common Stock [Member]
Settlement of Preferred Stock [Member]
Series D Preferred Stock [Member]
Common Stock [Member]
At-the-Market Offering [Member]
Series D Preferred Stock [Member]
Common Stock [Member]
Exercise of Options [Member]
Series D Preferred Stock [Member]
Common Stock [Member]
Exercise of Warrants [Member]
Series D Preferred Stock [Member]
Common Stock [Member]
Series E Preferred Stock [Member]
Additional Paid-in Capital [Member]
Settlement of Preferred Stock [Member]
Series E Preferred Stock [Member]
Additional Paid-in Capital [Member]
At-the-Market Offering [Member]
Series E Preferred Stock [Member]
Additional Paid-in Capital [Member]
Exercise of Options [Member]
Series E Preferred Stock [Member]
Additional Paid-in Capital [Member]
Exercise of Warrants [Member]
Series E Preferred Stock [Member]
Additional Paid-in Capital [Member]
Trek Therapeutics, PBC [Member]
Series E Preferred Stock [Member]
Additional Paid-in Capital [Member]
Series E Preferred Stock [Member]
Retained Earnings [Member]
Series C Preferred Stock [Member]
Settlement of Preferred Stock [Member]
Series C Preferred Stock [Member]
Noncontrolling Interest [Member]
Trek Therapeutics, PBC [Member]
Noncontrolling Interest [Member]
Cashless Exercise of Options [Member]
At-the-Market Offering [Member]
Exercise of Options [Member]
Exercise of Warrants [Member]
Trek Therapeutics, PBC [Member]
Total
Balance at Dec. 31, 2018             $ 17           $ 74,039 $ (70,732)                   $ 3,324
Balance (in Shares) at Dec. 31, 2018             16,868,783                                  
Common stock issued for services             $ 2           9,674                     9,676
Common stock issued for services (in Shares)             1,558,317                                  
Sale of common stock             $ 2           10,005                     10,007
Sale of common stock (in Shares)             2,386,462                                  
Sale of subsidiary shares to non-controlling interest                         4,081         $ 931           5,012
Common stock issued upon exercise of warrants             $ 2           7,469                     7,471
Common stock issued upon exercise of warrants (in Shares) 162,592           1,860,479                                  
Common stock issued in exchange for subsidiary shares (in Shares)                               90,714                
Common stock issued upon exercise of options                         938                     $ 938
Common stock issued upon exercise of options (in Shares)   92,788         189,620                       360,457   189,620     550,077
Common stock issued upon conversion of preferred stock and accrued dividends               $ 139         260   $ 139 $ 260                
Common stock issued upon conversion of preferred stock and accrued dividends (in Shares)     21,379       69,335                       92,788   938,034      
Fair value of warrants issued to acquire research and development                         3,162                     $ 3,162
Change in fair value of modified options                         666                     666
Stock based compensation                         5,502                     5,502
Stock based compensation (in Shares)             113,332                                  
Preferred Stock dividend                         (25)                     (25)
Net loss                           (34,055)       (416)           (34,471)
Balance at Dec. 31, 2019             $ 23           115,910 (104,787)       515           $ 11,661
Balance (in Shares) at Dec. 31, 2019             23,323,087                                 23,323,087
Common stock issued for services             $ 1           4,399                     $ 4,400
Common stock issued for services (in Shares)             679,555                                  
Fair value of subsidiary shares issued to acquire research and development                       $ 2,439 1,051       $ 735 248         $ 3,174 1,299
Sale of common stock             $ 5   $ 2,228       25,210             $ 2,228       25,215
Sale of common stock (in Shares)       424,357     4,687,500                                  
Sale of subsidiary shares to non-controlling interest                         7,124         3,468           $ 10,592
Common stock issued upon exercise of warrants           $ 1         $ 2,089                     $ 2,090    
Common stock issued upon exercise of warrants (in Shares) 12,840         542,646                                    
Common stock issued in exchange for subsidiary shares                         24         (24)            
Common stock issued in exchange for subsidiary shares (in Shares)             83,055                 44,850                
Common stock issued upon exercise of options         $ 1         $ 2,721                     $ 2,722      
Common stock issued upon exercise of options (in Shares)         586,825   160,743                       616,398   586,825     1,203,223
Common stock issued upon conversion of preferred stock and accrued dividends               $ 70         110   $ 70 $ 110                
Common stock issued upon conversion of preferred stock and accrued dividends (in Shares)     15,516       29,334                                  
Change in fair value of modified options                                               $ 0
Stock based compensation                         17,983         2,782           20,765
Stock based compensation (in Shares)             219,334                                  
Preferred Stock dividend                         (14)                     (14)
Net loss                           (52,218)       (6,922)           (59,140)
Balance at Dec. 31, 2020             $ 31           $ 181,344 $ (157,005)       $ 802           $ 25,172
Balance (in Shares) at Dec. 31, 2020             30,764,792                                 30,764,792