Annual report pursuant to Section 13 and 15(d)

CONSOLIDATED STATEMENT OF STOCKHOLDERS' EQUITY (DEFICIT) (Parentheticals)

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CONSOLIDATED STATEMENT OF STOCKHOLDERS' EQUITY (DEFICIT) (Parentheticals) - $ / shares
Dec. 31, 2018
Dec. 31, 2017
Preferred Stock [Member] | Series E Preferred Stock [Member]    
Conversion of preferred stock   $ 3.75
Common stock issued $ 4.08 $ 3.32
Exercise of Warrants [Member] | Common Stock [Member]    
Common stock issued 3.80  
Exercise of Options [Member] | Common Stock [Member]    
Common stock issued 4.40  
Series C Preferred Stock [Member] | Preferred Stock [Member] | Series E Preferred Stock [Member]    
Conversion of preferred stock 3.75  
Settlement of Preferred Stock [Member] | Preferred Stock [Member] | Series E Preferred Stock [Member]    
Common stock issued 4.19  
Settlement of Preferred Stock [Member] | Preferred Stock [Member] | Series D Preferred Stock [Member]    
Common stock issued 3.41  
Series D Preferred Stock [Member] | Preferred Stock [Member] | Series D Preferred Stock [Member]    
Conversion of preferred stock 3.75  
Series E Preferred Stock [Member] | Preferred Stock [Member] | Series E Preferred Stock [Member]    
Conversion of preferred stock $ 3.75