Quarterly report pursuant to Section 13 or 15(d)

CONDENSED CONSOLIDATED STATEMENT OF CHANGES IN EQUITY

CONDENSED CONSOLIDATED STATEMENT OF CHANGES IN EQUITY - USD ($)	Series D Preferred Stock [Member] Common Stock [Member] At-the-market Offering [Member]	Series D Preferred Stock [Member] Common Stock [Member] Exercise of Warrants [Member]	Series D Preferred Stock [Member] Common Stock [Member]	Series E Preferred Stock [Member] Additional Paid-in Capital [Member] At-the-market Offering [Member]	Series E Preferred Stock [Member] Additional Paid-in Capital [Member] Exercise of Warrants [Member]	Series E Preferred Stock [Member] Additional Paid-in Capital [Member]	Series E Preferred Stock [Member] Retained Earnings [Member]	Series C Preferred Stock [Member] Common Stock [Member] Settlement of Preferred Stock [Member]	Series C Preferred Stock [Member] Common Stock [Member]	Series C Preferred Stock [Member] Additional Paid-in Capital [Member] Settlement of Preferred Stock [Member]	Series C Preferred Stock [Member] Additional Paid-in Capital [Member]	Series C Preferred Stock [Member] Settlement of Preferred Stock [Member]	Series C Preferred Stock [Member]	Common Stock [Member] At-the-market Offering [Member]	Common Stock [Member] Exercise of Warrants [Member]	Common Stock [Member] Cashless Exercise of Warrants [Member]	Common Stock [Member] Cashless Exercise of Options [Member]	Common Stock [Member]	Additional Paid-in Capital [Member] Trek Therapeutics [Member]	Additional Paid-in Capital [Member] At-the-market Offering [Member]	Additional Paid-in Capital [Member] Exercise of Warrants [Member]	Additional Paid-in Capital [Member] Cashless Exercise of Warrants [Member]	Additional Paid-in Capital [Member] Cashless Exercise of Options [Member]	Additional Paid-in Capital [Member]	Retained Earnings [Member]	Noncontrolling Interest [Member] Trek Therapeutics [Member]	Noncontrolling Interest [Member]	Receivables from Stockholder [Member] Subscription Arrangement [Member]	Receivables from Stockholder [Member]	Trek Therapeutics [Member]	At-the-market Offering [Member]	Exercise of Warrants [Member]	Subscription Arrangement [Member]	Cashless Exercise of Options [Member]	Total
Balance at Dec. 31, 2018																		$ 16,869						$ 74,039,341	$ (70,731,941)										$ 3,324,269
Balance (in Shares) at Dec. 31, 2018																		16,868,783
Sale of common stock																		$ 2,155						8,617,123											8,619,278
Sale of common stock (in Shares)																		2,155,127
Common stock issued for services																		$ 973						5,802,455											5,803,428
Common stock issued for services (in Shares)																		973,317
Common stock issued upon conversion of preferred stock and accrued dividends								$ 21	$ 69	$ 139,571	$ 259,931	$ 139,592	$ 260,000
Common stock issued upon conversion of preferred stock and accrued dividends (in Shares)								21,379	69,335
Sale of subsidiary shares to non-controlling interest																								3,268,434			$ 426,212	$ 501,000					$ 501,000		3,694,646
Change in fair value of modified options																								666,062											666,062
Common stock issued upon exercise of options																	$ 39	$ 98					$ (39)	465,100											465,198
Common stock issued upon exercise of options (in Shares)																	38,687	97,500
Common stock issued upon exercise of warrants															$ 1,563	$ 162					$ 6,353,307	$ (162)										$ 6,354,870
Common stock issued upon exercise of warrants (in Shares)															1,562,896	161,986
Stock based compensation																		$ 83						1,892,775											1,892,858
Stock based compensation (in Shares)																		83,332
Preferred Stock dividend																								(20,286)											(20,286)
Net loss																									(19,262,618)		(20,538)								(19,283,156)
Balance at Sep. 30, 2019																		$ 22,032						101,483,612	(89,994,559)		405,674		$ 501,000						12,417,759
Balance (in Shares) at Sep. 30, 2019																		22,032,342
Balance at Jun. 30, 2019																		$ 21,151						94,494,972	(84,551,093)										9,965,030
Balance (in Shares) at Jun. 30, 2019																		21,151,134
Common stock issued for services																		$ 413						1,196,215											1,196,628
Common stock issued for services (in Shares)																		413,317
Sale of subsidiary shares to non-controlling interest																								3,268,434			426,212	$ 501,000					$ 501,000		3,694,646
Common stock issued upon exercise of options																		$ 4						20,356											20,360
Common stock issued upon exercise of options (in Shares)																		4,000
Common stock issued upon exercise of warrants															$ 433	$ 1					1,735,950	(1)										1,736,383
Common stock issued upon exercise of warrants (in Shares)															432,867	1,024
Stock based compensation																		$ 30						772,563											772,593
Stock based compensation (in Shares)																		30,000
Preferred Stock dividend																								(4,877)											(4,877)
Net loss																									(5,443,466)		(20,538)								(5,464,004)
Balance at Sep. 30, 2019																		$ 22,032						101,483,612	(89,994,559)		405,674		$ 501,000						12,417,759
Balance (in Shares) at Sep. 30, 2019																		22,032,342
Balance at Dec. 31, 2019																		$ 23,323						115,910,058	(104,786,769)		514,828								$ 11,661,440
Balance (in Shares) at Dec. 31, 2019																		23,323,087																	23,323,087
Sale of common stock														$ 150				$ 4,688		$ 1,001,613				25,209,623							$ 1,001,763				$ 25,214,311
Sale of common stock (in Shares)														150,000				4,687,500
Common stock issued for services																		$ 503						3,550,401											$ 3,550,904
Common stock issued for services (in Shares)																		503,038																	503,038
Fair value of subsidiary shares issued to acquire research and development																			$ 2,439,139					1,051,309		$ 735,411	248,486			$ 3,174,550					$ 1,299,795
Common stock issued upon conversion of preferred stock and accrued dividends								$ 16	$ 29	$ 70,325	$ 109,971	$ 70,341	$ 110,000
Common stock issued upon conversion of preferred stock and accrued dividends (in Shares)								15,516	29,334
Sale of subsidiary shares to non-controlling interest																								7,124,366		$ 983,897	3,467,709								10,592,075
Common stock issued upon exercise of options																	$ 161	$ 586					$ (161)	2,721,426											$ 2,722,012
Common stock issued upon exercise of options (in Shares)																	160,743	586,825																616,398	1,203,223
Common stock issued upon exercise of warrants															$ 430	$ 13					$ 1,666,065	$ (13)										1,666,495
Common stock issued upon exercise of warrants (in Shares)															429,979	12,840
Stock based compensation																		$ 219						14,385,910			2,636,298								$ 17,022,427
Stock based compensation (in Shares)																		219,334
Preferred Stock dividend																								(11,698)											(11,698)
Net loss																									(41,925,704)		(6,282,420)								(48,208,124)
Balance at Sep. 30, 2020			$ 30,118			$ 175,228,334	$ (146,712,473)											$ 30,118						175,228,334	(146,712,473)		1,320,312								$ 29,866,291
Balance (in Shares) at Sep. 30, 2020			30,118,196															30,118,196																	30,118,196
Balance at Jun. 30, 2020			$ 29,127			168,499,417	(135,310,614)																				2,793,950								$ 36,011,880
Balance (in Shares) at Jun. 30, 2020			29,126,663
Sale of common stock	$ 150			$ 1,001,613																											$ 1,001,763
Sale of common stock (in Shares)	150,000
Common stock issued for services			$ 488			3,442,142																													3,442,630
Common stock issued for services (in Shares)			488,000
Common stock issued upon exercise of options			$ 108			492,424																													492,532
Common stock issued upon exercise of options (in Shares)			108,374
Common stock issued upon exercise of warrants		$ 160			$ 632,039																											$ 632,199
Common stock issued upon exercise of warrants (in Shares)		160,159
Stock based compensation			$ 85			1,163,080																					222,944								1,386,109
Stock based compensation (in Shares)			85,000
Preferred Stock dividend						(2,381)																													(2,381)
Net loss							(11,401,859)																				(1,696,582)								(13,098,441)
Balance at Sep. 30, 2020			$ 30,118			$ 175,228,334	$ (146,712,473)											$ 30,118						$ 175,228,334	$ (146,712,473)		$ 1,320,312								$ 29,866,291
Balance (in Shares) at Sep. 30, 2020			30,118,196															30,118,196																	30,118,196