Quarterly report pursuant to Section 13 or 15(d)

CONDENSED CONSOLIDATED STATEMENT OF STOCKHOLDERS' EQUITY (DEFICIT)

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CONDENSED CONSOLIDATED STATEMENT OF STOCKHOLDERS' EQUITY (DEFICIT) - USD ($)
Series D Preferred Stock [Member]
At-the-Market Offering [Member]
Common Stock [Member]
Series D Preferred Stock [Member]
Settlement of Preferred Stock [Member]
Common Stock [Member]
Series D Preferred Stock [Member]
Cashless Exercise of Warrants [Member]
Common Stock [Member]
Series D Preferred Stock [Member]
Exercise of Warrants [Member]
Common Stock [Member]
Series D Preferred Stock [Member]
Cashless Exercise of Options [Member]
Common Stock [Member]
Series D Preferred Stock [Member]
Common Stock [Member]
Series E Preferred Stock [Member]
At-the-Market Offering [Member]
Additional Paid-in Capital [Member]
Series E Preferred Stock [Member]
Settlement of Preferred Stock [Member]
Additional Paid-in Capital [Member]
Series E Preferred Stock [Member]
Exercise of Warrants [Member]
Additional Paid-in Capital [Member]
Series E Preferred Stock [Member]
Trek Therapeutics, PBC [Member]
Additional Paid-in Capital [Member]
Series E Preferred Stock [Member]
Additional Paid-in Capital [Member]
Series E Preferred Stock [Member]
Retained Earnings [Member]
Series C Preferred Stock [Member]
Settlement of Preferred Stock [Member]
Series C Preferred Stock [Member]
At-the-Market Offering [Member]
Exercise of Warrants [Member]
Trek Therapeutics, PBC [Member]
Noncontrolling Interest [Member]
Trek Therapeutics, PBC [Member]
Noncontrolling Interest [Member]
Total
Balance at Dec. 31, 2019           $ 23,000         $ 115,910,000 $ (104,787,000)             $ 515,000 $ 11,661,000
Balance (in Shares) at Dec. 31, 2019           23,323,087                            
Common stock issued upon exercise of options (in Shares)           11,141                            
Sale of common stock           $ 2,000         9,050,000                 9,052,000
Sale of common stock (in Shares)           2,500,000                            
Common stock issued upon conversion of preferred stock and accrued dividends               $ 6,000     10,000   $ 6,000 $ 10,000            
Common stock issued upon conversion of preferred stock and accrued dividends (in Shares)   1,083       2,667                            
Common stock issued upon exercise of warrants       $ 1,000         $ 301,000             $ 302,000        
Common stock issued upon exercise of warrants (in Shares)     10,574 80,432                                
Fair value of subsidiary shares issued to acquire research and development                   $ 2,440,000             $ 735,000 $ 3,175,000    
Stock based compensation                     3,628,000               785,000 4,413,000
Stock based compensation (in Shares)           81,334                            
Preferred Stock dividend                     (5,000)                 (5,000)
Net loss                       (11,335,000)             (1,428,000) (12,763,000)
Balance at Mar. 31, 2020           $ 26,000         131,340,000 (116,122,000)             607,000 15,851,000
Balance (in Shares) at Mar. 31, 2020           26,010,318                            
Balance at Dec. 31, 2019           $ 23,000         115,910,000 (104,787,000)             515,000 11,661,000
Balance (in Shares) at Dec. 31, 2019           23,323,087                            
Preferred Stock dividend                                       (9,000)
Net loss                                       (35,110,000)
Balance at Jun. 30, 2020           $ 29,000         168,499,000 (135,310,000)             2,794,000 36,012,000
Balance (in Shares) at Jun. 30, 2020           29,126,663                            
Balance at Dec. 31, 2019           $ 23,000         115,910,000 (104,787,000)             515,000 11,661,000
Balance (in Shares) at Dec. 31, 2019           23,323,087                            
Common stock issued for services                                       $ 2,658,224
Common stock issued for services (in Shares)                                       658,868
Balance at Dec. 31, 2020           $ 31,000         181,344,000 (157,005,000)             802,000 $ 25,172,000
Balance (in Shares) at Dec. 31, 2020           30,764,792                           30,764,792
Balance at Mar. 31, 2020           $ 26,000         131,340,000 (116,122,000)             607,000 $ 15,851,000
Balance (in Shares) at Mar. 31, 2020           26,010,318                            
Common stock issued for services                     108,000                 108,000
Common stock issued for services (in Shares)           15,038                            
Common stock issued upon exercise of options           $ 1,000         2,228,000                 2,229,000
Common stock issued upon exercise of options (in Shares)         149,602 478,451                            
Sale of common stock           $ 2,000         16,160,000                 16,162,000
Sale of common stock (in Shares)           2,187,500                            
Sale of subsidiary shares to non-controlling interest                     7,124,000               3,468,000 10,592,000
Common stock issued upon conversion of preferred stock and accrued dividends               $ 65,000     100,000   $ 65,000 $ 100,000            
Common stock issued upon conversion of preferred stock and accrued dividends (in Shares)   14,433       26,667                            
Common stock issued upon exercise of warrants                 $ 733,000             $ 733,000        
Common stock issued upon exercise of warrants (in Shares)     2,266 189,388                                
Fair value of subsidiary shares issued to acquire research and development                     1,051,000               249,000 1,300,000
Stock based compensation                     9,595,000               1,628,000 11,223,000
Stock based compensation (in Shares)           53,000                            
Preferred Stock dividend                     (5,000)                 (5,000)
Net loss                       (19,188,000)             (3,158,000) (22,346,000)
Balance at Jun. 30, 2020           $ 29,000         168,499,000 (135,310,000)             2,794,000 36,012,000
Balance (in Shares) at Jun. 30, 2020           29,126,663                            
Balance at Dec. 31, 2020           $ 31,000         181,344,000 (157,005,000)             802,000 $ 25,172,000
Balance (in Shares) at Dec. 31, 2020           30,764,792                           30,764,792
Common stock issued for services                     1,777,000                 $ 1,777,000
Common stock issued for services (in Shares)           406,692                            
Common stock issued upon exercise of options                     28,000                 28,000
Common stock issued upon exercise of options (in Shares)           9,375                            
Sale of common stock             $ 1,300,000               $ 1,300,000          
Sale of common stock (in Shares) 251,720                                      
Stock based compensation           $ 1,000         721,000               20,000 742,000
Stock based compensation (in Shares)           682,202                            
Preferred Stock dividend                     (2,000)                 (2,000)
Net loss                       (8,319,000)             (240,000) (8,559,000)
Balance at Mar. 31, 2021           $ 32,000         185,168,000 (165,324,000)             582,000 20,458,000
Balance (in Shares) at Mar. 31, 2021           32,114,781                            
Balance at Dec. 31, 2020           $ 31,000         181,344,000 (157,005,000)             802,000 $ 25,172,000
Balance (in Shares) at Dec. 31, 2020           30,764,792                           30,764,792
Common stock issued for services                                       $ 1,917,000
Common stock issued for services (in Shares)                                       443,640
Common stock issued upon exercise of options (in Shares)                                       9,375
Preferred Stock dividend                                       $ (5,000)
Net loss                                       (16,610,000)
Balance at Jun. 30, 2021           $ 32,000         187,136,000 (173,025,000)             374,000 $ 14,517,000
Balance (in Shares) at Jun. 30, 2021           32,205,479                           32,205,479
Balance at Mar. 31, 2021           $ 32,000         185,168,000 (165,324,000)             582,000 $ 20,458,000
Balance (in Shares) at Mar. 31, 2021           32,114,781                            
Common stock issued for services                     140,000                 140,000
Common stock issued for services (in Shares)           36,948                            
Change in fair value of modified options                     313,000               8,000 321,000
Stock based compensation                     1,518,000               134,000 1,652,000
Stock based compensation (in Shares)           53,750                            
Preferred Stock dividend                     (3,000)                 (3,000)
Net loss                       (7,701,000)             (350,000) (8,051,000)
Balance at Jun. 30, 2021           $ 32,000         $ 187,136,000 $ (173,025,000)             $ 374,000 $ 14,517,000
Balance (in Shares) at Jun. 30, 2021           32,205,479                           32,205,479