Quarterly report pursuant to Section 13 or 15(d)

CONDENSED CONSOLIDATED STATEMENT OF STOCKHOLDERS' EQUITY (DEFICIT)

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CONDENSED CONSOLIDATED STATEMENT OF STOCKHOLDERS' EQUITY (DEFICIT) - USD ($)
Series D Preferred Stock [Member]
Common Stock [Member]
At-the-Market Offering [Member]
Series D Preferred Stock [Member]
Common Stock [Member]
Settlement of Preferred Stock [Member]
Series D Preferred Stock [Member]
Common Stock [Member]
Cashless Exercise of Warrants [Member]
Series D Preferred Stock [Member]
Common Stock [Member]
Exercise of Warrants [Member]
Series D Preferred Stock [Member]
Common Stock [Member]
Cashless Exercise of Options [Member]
Series D Preferred Stock [Member]
Common Stock [Member]
Series E Preferred Stock [Member]
Additional Paid-in Capital [Member]
At-the-Market Offering [Member]
Series E Preferred Stock [Member]
Additional Paid-in Capital [Member]
Settlement of Preferred Stock [Member]
Series E Preferred Stock [Member]
Additional Paid-in Capital [Member]
Exercise of Warrants [Member]
Series E Preferred Stock [Member]
Additional Paid-in Capital [Member]
Trek Therapeutics, PBC [Member]
Series E Preferred Stock [Member]
Additional Paid-in Capital [Member]
Series E Preferred Stock [Member]
Retained Earnings [Member]
Series C Preferred Stock [Member]
Settlement of Preferred Stock [Member]
Series C Preferred Stock [Member]
Noncontrolling Interest [Member]
Trek Therapeutics, PBC [Member]
Noncontrolling Interest [Member]
At-the-Market Offering [Member]
Exercise of Warrants [Member]
Trek Therapeutics, PBC [Member]
Total
Balance at Dec. 31, 2019           $ 23,000         $ 115,910,000 $ (104,786,000)       $ 515,000       $ 11,662,000
Balance (in Shares) at Dec. 31, 2019           23,323,087                            
Common stock issued upon exercise of options (in Shares)           11,141                            
Sale of common stock           $ 2,000         9,050,000                 9,052,000
Sale of common stock (in Shares)           2,500,000                            
Common stock issued upon conversion of preferred stock and accrued dividends               $ 6,000     10,000   $ 6,000 $ 10,000            
Common stock issued upon conversion of preferred stock and accrued dividends (in Shares)   1,083       2,667                            
Common stock issued upon exercise of warrants       $ 1,000         $ 301,000                 $ 302,000    
Common stock issued upon exercise of warrants (in Shares)     10,574 80,432                                
Fair value of subsidiary shares issued to acquire research and development                   $ 2,440,000         $ 735,000       $ 3,175,000  
Stock based compensation                     3,628,000         785,000       4,413,000
Stock based compensation (in Shares)           81,334                            
Preferred Stock dividend                     (5,000)                 (5,000)
Net loss                       (11,336,000)       (1,428,000)       (12,764,000)
Balance at Mar. 31, 2020           $ 26,000         131,340,000 (116,122,000)       607,000       15,851,000
Balance (in Shares) at Mar. 31, 2020           26,010,318                            
Balance at Dec. 31, 2019           $ 23,000         115,910,000 (104,786,000)       515,000       11,662,000
Balance (in Shares) at Dec. 31, 2019           23,323,087                            
Preferred Stock dividend                                       (11,000)
Net loss                                       (48,208,000)
Balance at Sep. 30, 2020           $ 30,000         175,228,000 (146,712,000)       1,320,000       29,866,000
Balance (in Shares) at Sep. 30, 2020           30,118,196                            
Balance at Mar. 31, 2020           $ 26,000         131,340,000 (116,122,000)       607,000       15,851,000
Balance (in Shares) at Mar. 31, 2020           26,010,318                            
Common stock issued for services                     108,000                 108,000
Common stock issued for services (in Shares)           15,038                            
Common stock issued upon exercise of options           $ 1,000         2,228,000                 2,229,000
Common stock issued upon exercise of options (in Shares)         149,602 478,451                            
Sale of common stock           $ 2,000         16,160,000                 16,162,000
Sale of common stock (in Shares)           2,187,500                            
Sale of subsidiary shares to non-controlling interest                     7,124,000         3,468,000       10,592,000
Common stock issued upon conversion of preferred stock and accrued dividends               $ 65,000     100,000   $ 65,000 $ 100,000            
Common stock issued upon conversion of preferred stock and accrued dividends (in Shares)   14,433       26,667                            
Common stock issued upon exercise of warrants                 $ 733,000                 $ 733,000    
Common stock issued upon exercise of warrants (in Shares)     2,266 189,388                                
Fair value of subsidiary shares issued to acquire research and development                     1,051,000         249,000       1,300,000
Stock based compensation                     9,595,000         1,628,000       11,223,000
Stock based compensation (in Shares)           53,000                            
Preferred Stock dividend                     (5,000)                 (5,000)
Net loss                       (19,188,000)       (3,158,000)       (22,346,000)
Balance at Jun. 30, 2020           $ 29,000         168,499,000 (135,310,000)       2,794,000       36,012,000
Balance (in Shares) at Jun. 30, 2020           29,126,663                            
Common stock issued for services           $ 1,000         3,442,000                 3,443,000
Common stock issued for services (in Shares)           488,000                            
Common stock issued upon exercise of options                     492,000                 492,000
Common stock issued upon exercise of options (in Shares)           108,374                            
Sale of common stock                     1,002,000                 1,002,000
Sale of common stock (in Shares)           150,000                            
Common stock issued upon exercise of warrants                     632,000                 632,000
Common stock issued upon exercise of warrants (in Shares)           160,159                            
Stock based compensation                     1,163,000         222,000       1,385,000
Stock based compensation (in Shares)           85,000                            
Preferred Stock dividend                     (2,000)                 (2,000)
Net loss                       (11,402,000)       (1,696,000)       (13,098,000)
Balance at Sep. 30, 2020           $ 30,000         175,228,000 (146,712,000)       1,320,000       29,866,000
Balance (in Shares) at Sep. 30, 2020           30,118,196                            
Balance at Dec. 31, 2020           $ 31,000         181,344,000 (157,005,000)       802,000       $ 25,172,000
Balance (in Shares) at Dec. 31, 2020           30,764,792                           30,764,792
Common stock issued for services                     1,777,000                 $ 1,777,000
Common stock issued for services (in Shares)           406,692                            
Common stock issued upon exercise of options                     28,000                 28,000
Common stock issued upon exercise of options (in Shares)           9,375                            
Sale of common stock             $ 1,300,000                   $ 1,300,000      
Sale of common stock (in Shares) 251,720                                      
Stock based compensation           $ 1,000         721,000         20,000       742,000
Stock based compensation (in Shares)           682,202                            
Preferred Stock dividend                     (2,000)                 (2,000)
Net loss                       (8,319,000)       (240,000)       (8,559,000)
Balance at Mar. 31, 2021           $ 32,000         185,168,000 (165,324,000)       582,000       20,458,000
Balance (in Shares) at Mar. 31, 2021           32,114,781                            
Balance at Dec. 31, 2020           $ 31,000         181,344,000 (157,005,000)       802,000       $ 25,172,000
Balance (in Shares) at Dec. 31, 2020           30,764,792                           30,764,792
Common stock issued for services                                       $ 3,271,340
Common stock issued for services (in Shares)                                       853,271
Common stock issued upon exercise of options (in Shares)                                       9,375
Preferred Stock dividend                                       $ (7,000)
Net loss                                       (23,857,000)
Balance at Sep. 30, 2021           $ 35,000         198,380,000 (180,278,000)       438,000       $ 18,575,000
Balance (in Shares) at Sep. 30, 2021           35,254,860                           35,254,860
Balance at Mar. 31, 2021           $ 32,000         185,168,000 (165,324,000)       582,000       $ 20,458,000
Balance (in Shares) at Mar. 31, 2021           32,114,781                            
Common stock issued for services                     140,000                 140,000
Common stock issued for services (in Shares)           36,948                            
Change in fair value of modified options                     313,000         8,000       321,000
Stock based compensation                     1,518,000         134,000       1,652,000
Stock based compensation (in Shares)           53,750                            
Preferred Stock dividend                     (3,000)                 (3,000)
Net loss                       (7,701,000)       (350,000)       (8,051,000)
Balance at Jun. 30, 2021           $ 32,000         187,136,000 (173,025,000)       374,000       14,517,000
Balance (in Shares) at Jun. 30, 2021           32,205,479                            
Common stock issued for services                     1,354,000                 1,354,000
Common stock issued for services (in Shares)           409,631                            
Sale of common stock           $ 3,000         9,002,000                 9,005,000
Sale of common stock (in Shares)           2,500,000                            
Stock based compensation                     890,000         58,000       948,000
Stock based compensation (in Shares)           139,750                            
Preferred Stock dividend                     (2,000)                 (2,000)
Net loss                       (7,253,000)       6,000       (7,247,000)
Balance at Sep. 30, 2021           $ 35,000         $ 198,380,000 $ (180,278,000)       $ 438,000       $ 18,575,000
Balance (in Shares) at Sep. 30, 2021           35,254,860                           35,254,860