Annual report pursuant to Section 13 and 15(d)

CONSOLIDATED STATEMENT OF STOCKHOLDERS' EQUITY (DEFICIT) (Parentheticals)

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CONSOLIDATED STATEMENT OF STOCKHOLDERS' EQUITY (DEFICIT) (Parentheticals)
12 Months Ended
Dec. 31, 2021
USD ($)
$ / shares
Dec. 31, 2020
USD ($)
$ / shares
Sale of common stock, transactional costs (in Dollars) | $ $ 995,000  
Options, per share $ 2.96 $ 5.08
Warrants, per share   $ 3.75
At-the-Market Offering [Member]    
Sale of common stock, transactional costs (in Dollars) | $ $ 40,000 $ 222,000
Series D Preferred Stock [Member] | Common Stock [Member]    
Preferred Stock, per share   $ 3.75
Series D Preferred Stock [Member] | Common Stock [Member] | Settlement of Preferred Stock [Member]    
Preferred Stock, per share   4.53
Options, per share $ 2.96  
Series D Preferred Stock [Member] | Common Stock [Member] | Exercise of Options [Member]    
Options, per share   4.64
Series D Preferred Stock [Member] | Common Stock [Member] | Exercise of Warrants [Member]    
Warrants, per share   $ 3.88